Mercury Theater Chicago is located in the Southport Corridor; a sophisticated neighborhood of restaurants and boutiques close to Wrigley Field. A delightful destination, Mercury Theater Chicago is a live-theater seating 280 people, adjoining Venus Cabaret Theater (seating 80) and a farm-to-table restaurant called Grassroots.

The building that houses the Mercury opened in 1912 as a silent film nickelodeon, named The Blaine Theatre after actor and former Senator and Secretary of State James G. Blaine. The Blaine became obsolete when talking pictures became popular nationwide in 1928. The much larger Music Box Theatre was then built, which is still in operation today. Though little of the original Blaine is left, some remnants still exist including the decorative plaster busts flanking the House. The intimate theater now boasts warm exposed brick walls and seats that were recovered and refurbished from a 1933 era Boston movie house.

Today Mercury Theater Chicago is led by Executive Director L. Walter Stearns, a veteran theater director and former Artistic Director of Porchlight Music Theatre. It re-opened May 1, 2011 with the critically acclaimed production of A Twist of Water. The Mercury is thrilled to be part of the city's vibrant theatre community, boasting multiple extensions of the critically-acclaimed production Avenue Q in 2014, Jeff Award wins for The Addams Family and The Man Who Murdered Sherlock Holmes, and establishing a new annual holiday tradition with the heartwarming holiday musical The Christmas Schooner.